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Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells
Abnormal amplification of centrosomes, which occurs frequently in cancers, leads to high frequencies of mitotic defect and chromosome segregation error, profoundly affecting the rate of tumor progression. Centrosome amplification results primarily from overduplication of centrosomes, and p53 is invo...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2574884/ https://ncbi.nlm.nih.gov/pubmed/18490919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.161 |
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