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Cyclin B2 and p53 control proper timing of centrosome separation
Cyclins Bl and B2 are frequently elevated in human cancers and are associated with tumour aggressiveness and poor clinical outcome; however, whether and how B-type cyclins drive tumorigenesis is unknown. Here we show that cyclin Bl and B2 transgenic mice are highly prone to tumours, including tumour...
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| Udgivet i: | Nat Cell Biol |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4379487/ https://ncbi.nlm.nih.gov/pubmed/24776885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2952 |
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