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Cyclin B1–Cdk1 Activation Continues after Centrosome Separation to Control Mitotic Progression
Activation of cyclin B1–cyclin-dependent kinase 1 (Cdk1), triggered by a positive feedback loop at the end of G2, is the key event that initiates mitotic entry. In metaphase, anaphase-promoting complex/cyclosome–dependent destruction of cyclin B1 inactivates Cdk1 again, allowing mitotic exit and cel...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1858714/ https://ncbi.nlm.nih.gov/pubmed/17472438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0050123 |
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