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The APC/C recruits cyclin B1–Cdk1–Cks in prometaphase before D box recognition to control mitotic exit
The ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C) is activated at prometaphase by mitotic phosphorylation and binding of its activator, Cdc20. This initiates cyclin A degradation, whereas cyclin B1 is stabilized by the spindle checkpoint. Upon checkpoint release, the RXXL destruction...
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| Hoofdauteurs: | , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The Rockefeller University Press
2010
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2928021/ https://ncbi.nlm.nih.gov/pubmed/20733055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200912084 |
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