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1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase

1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes (C-DIMs) activate the orphan receptors peroxisome proliferator-activated receptor γ (PPARγ) and Nur77 and induce receptor-dependent and -independent apoptotic pathways in colon and other cancer cells. Structure-activity studies show that the p-bro...

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Dettagli Bibliografici
Autori principali: Lei, Ping, Abdelrahim, Maen, Cho, Sung Dae, Liu, Shengxi, Chintharlapalli, Sudhakar, Safe, Stephen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574736/
https://ncbi.nlm.nih.gov/pubmed/18460448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgn103
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