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The Application of Molecular Modeling for Prediction of Substrate Specificity in Cytochrome P450 1A2 Mutants
Molecular dynamics (MD) simulations of 7-ethoxy and 7-methoxyresorufin bound in the active site of P450 1A2 wild type and various mutants were used to predict changes in substrate specificity of the mutants. A total of 26 multiple mutants representing all possible combinations of five key amino acid...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2574645/ https://ncbi.nlm.nih.gov/pubmed/18703643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.022640 |
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