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Passive Transfer of Polyethylene glycol to Liposomal-Recombinant Human FVIII Enhances its Efficacy in a Murine Model for Hemophilia A

The replacement therapy using recombinant human FVIII (rFVIII) is the first line of therapy for hemophilia A. Approximately 15-30% of the patients develop inhibitory antibodies. Recently, we reported that liposomes composed of phosphatidylserine (PS) could reduce the immunogenicity of rFVIII. Howeve...

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מידע ביבליוגרפי
Main Authors: RAMANI, KARTHIK, PUROHIT, VIVEK, MICLEA, RAZVAN, GAITONDE, PUNEET, STRAUBINGER, ROBERT M., BALU-IYER, SATHY V.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574432/
https://ncbi.nlm.nih.gov/pubmed/18300296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.21266
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