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Charge Cluster-to-Alanine Scanning of UL128 for Fine Tuning of the Endothelial Cell Tropism of Human Cytomegalovirus

The viral genes UL128, UL130, and UL131A have been identified as major determinants of endothelial cell (EC) tropism of human cytomegalovirus (HCMV), with deletion of either gene causing a null phenotype. We hypothesized that a functional scanning of these genes by minor genetic modifications would...

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Main Authors: Schuessler, Andrea, Sampaio, Kerstin Laib, Sinzger, Christian
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology (ASM) 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573262/
https://ncbi.nlm.nih.gov/pubmed/18768970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01069-08
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