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Charge Cluster-to-Alanine Scanning of UL128 for Fine Tuning of the Endothelial Cell Tropism of Human Cytomegalovirus

The viral genes UL128, UL130, and UL131A have been identified as major determinants of endothelial cell (EC) tropism of human cytomegalovirus (HCMV), with deletion of either gene causing a null phenotype. We hypothesized that a functional scanning of these genes by minor genetic modifications would...

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Autores principales: Schuessler, Andrea, Sampaio, Kerstin Laib, Sinzger, Christian
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573262/
https://ncbi.nlm.nih.gov/pubmed/18768970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01069-08
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