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Mutational Mapping of UL130 of Human Cytomegalovirus Defines Peptide Motifs within the C-Terminal Third as Essential for Endothelial Cell Infection

The UL130 gene is one of the major determinants of endothelial cell (EC) tropism of human cytomegalovirus (HCMV). In order to define functionally important peptides within this protein, we have performed a charge-cluster-to-alanine (CCTA) mutational scanning of UL130 in the genetic background of a b...

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Detalhes bibliográficos
Main Authors: Schuessler, Andrea, Sampaio, Kerstin Laib, Scrivano, Laura, Sinzger, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937617/
https://ncbi.nlm.nih.gov/pubmed/20592093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00572-10
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