pH-Induced Activation of Arenavirus Membrane Fusion Is Antagonized by Small-Molecule Inhibitors

The arenavirus envelope glycoprotein (GPC) mediates viral entry through pH-induced membrane fusion in the endosome. This crucial process in the viral life cycle can be specifically inhibited in the New World arenaviruses by the small-molecule compound ST-294. Here, we show that ST-294 interferes wit...

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Bibliographic Details
Main Authors: York, Joanne, Dai, Dongcheng, Amberg, Sean M., Nunberg, Jack H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573205/
https://ncbi.nlm.nih.gov/pubmed/18768973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01140-08
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