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Myristoylation of the Arenavirus Envelope Glycoprotein Stable Signal Peptide Is Critical for Membrane Fusion but Dispensable for Virion Morphogenesis

Arenaviruses are responsible for severe and often fatal hemorrhagic disease. In the absence of effective antiviral therapies and vaccines, these viruses pose serious threats to public health and biodefense. Arenaviruses enter the host cell by fusion of the viral and endosomal membranes, a process me...

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Detalles Bibliográficos
Publicado en:J Virol
Autores principales: York, Joanne, Nunberg, Jack H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008094/
https://ncbi.nlm.nih.gov/pubmed/27412594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01124-16
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