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Myristoylation of the Arenavirus Envelope Glycoprotein Stable Signal Peptide Is Critical for Membrane Fusion but Dispensable for Virion Morphogenesis

Arenaviruses are responsible for severe and often fatal hemorrhagic disease. In the absence of effective antiviral therapies and vaccines, these viruses pose serious threats to public health and biodefense. Arenaviruses enter the host cell by fusion of the viral and endosomal membranes, a process me...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: York, Joanne, Nunberg, Jack H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008094/
https://ncbi.nlm.nih.gov/pubmed/27412594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01124-16
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