In Vitro Activities of ER-119884 and E5700, Two Potent Squalene Synthase Inhibitors, against Leishmania amazonensis: Antiproliferative, Biochemical, and Ultrastructural Effects

ER-119884 and E5700, novel arylquinuclidine derivatives developed as cholesterol-lowering agents, were potent in vitro growth inhibitors of both proliferative stages of Leishmania amazonensis, the main causative agent of cutaneous leishmaniasis in South America, with the 50% inhibitory concentration...

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Autores principales: Fernandes Rodrigues, Juliany Cola, Concepcion, Juan Luis, Rodrigues, Carlos, Caldera, Aura, Urbina, Julio A., de Souza, Wanderley
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2008
Materias:
Susceptibility
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573141/
https://ncbi.nlm.nih.gov/pubmed/18765694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01616-07
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