Ultrastructural and Biochemical Alterations Induced by 22,26-Azasterol, a Δ(24(25))-Sterol Methyltransferase Inhibitor, on Promastigote and Amastigote Forms of Leishmania amazonensis

We report on the antiproliferative effects and the ultrastructural and biochemical alterations induced in vitro by 22,26-azasterol, a sterol Δ(24(25))-methyltransferase (24-SMT) inhibitor, on Leishmania amazonensis. When promastigotes and amastigotes were exposed to 100 nM 22,26-azasterol, complete...

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Detalhes bibliográficos
Main Authors: Rodrigues, Juliany C. F., Attias, Márcia, Rodriguez, Carlos, Urbina, Julio A., Souza, Wanderley de
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127026/
https://ncbi.nlm.nih.gov/pubmed/11796362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.2.487-499.2002
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