Ultrastructural and Biochemical Alterations Induced by 22,26-Azasterol, a Δ(24(25))-Sterol Methyltransferase Inhibitor, on Promastigote and Amastigote Forms of Leishmania amazonensis

We report on the antiproliferative effects and the ultrastructural and biochemical alterations induced in vitro by 22,26-azasterol, a sterol Δ(24(25))-methyltransferase (24-SMT) inhibitor, on Leishmania amazonensis. When promastigotes and amastigotes were exposed to 100 nM 22,26-azasterol, complete...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Rodrigues, Juliany C. F., Attias, Márcia, Rodriguez, Carlos, Urbina, Julio A., Souza, Wanderley de
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Mechanisms of Action: Physiological Effects
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127026/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11796362/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.2.487-499.2002
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