In Vitro and In Vivo Activities of E5700 and ER-119884, Two Novel Orally Active Squalene Synthase Inhibitors, against Trypanosoma cruzi

Chagas' disease is a serious public health problem in Latin America, and no treatment is available for the prevalent chronic stage. Its causative agent, Trypanosoma cruzi, requires specific endogenous sterols for survival, and we have recently demonstrated that squalene synthase (SQS) is a prom...

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מידע ביבליוגרפי
Main Authors: Urbina, Julio A., Concepcion, Juan Luis, Caldera, Aura, Payares, Gilberto, Sanoja, Cristina, Otomo, Takeshi, Hiyoshi, Hironobu
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2004
נושאים:
Experimental Therapeutics
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC434216/
https://ncbi.nlm.nih.gov/pubmed/15215084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.7.2379-2387.2004
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