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Telomerase activity of HIV-1–specific CD8(+) T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors
Exhaustion of virus-specific T cells may play an important role in the pathophysiology of chronic viral infections. Here, we analyzed telomere length and telomerase activity in HIV-1–specific CD8(+) T cells from progressors or controllers to determine underlying molecular pathways of T-cell exhausti...
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| 主要な著者: | , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2572795/ https://ncbi.nlm.nih.gov/pubmed/18728248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-135442 |
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