The GET Complex Mediates Insertion of Tail-Anchored Proteins into the ER Membrane

Tail-anchored (TA) proteins, defined by the presence of a single C-terminal transmembrane domain (TMD), play critical roles throughout the secretory pathway and in mitochondria, yet the machinery responsible for their proper membrane insertion remains poorly characterized. Here we show that Get3, th...

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Detalhes bibliográficos
Main Authors: Schuldiner, Maya, Metz, Jutta, Schmid, Volker, Denic, Vladimir, Rakwalska, Magdalena, Schmitt, Hans Dieter, Schwappach, Blanche, Weissman, Jonathan S.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572727/
https://ncbi.nlm.nih.gov/pubmed/18724936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.06.025
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