Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment

Thymic T cell lineage commitment is dependent on Notch1 (N1) receptor–mediated signaling. Although the physiological ligands that interact with N1 expressed on thymic precursors are currently unknown, in vitro culture systems point to Delta-like 1 (DL1) and DL4 as prime candidates. Using DL1- and DL...

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Detalhes bibliográficos
Main Authors: Koch, Ute, Fiorini, Emma, Benedito, Rui, Besseyrias, Valerie, Schuster-Gossler, Karin, Pierres, Michel, Manley, Nancy R., Duarte, Antonio, MacDonald, H. Robson, Radtke, Freddy
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Brief Definitive Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2571927/
https://ncbi.nlm.nih.gov/pubmed/18824585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080829
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