MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease

Hyperproliferation of bile duct epithelial cells due to cell-cycle dysregulation is a key feature of cystogenesis in polycystic liver diseases (PCLDs). Recent evidence suggests a regulatory role for microRNAs (miRNAs) in a variety of biological processes, including cell proliferation. We therefore h...

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Detalhes bibliográficos
Main Authors: Lee, Seung-Ok, Masyuk, Tatyana, Splinter, Patrick, Banales, Jesús M., Masyuk, Anatoliy, Stroope, Angela, LaRusso, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2571032/
https://ncbi.nlm.nih.gov/pubmed/18949056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34922
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