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Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression
Somatic hypermutation (SHM) and class-switch recombination (CSR) of Ig genes are dependent upon activation-induced cytidine deaminase (AID)-induced mutations. The scaffolding properties of proliferating cell nuclear antigen (PCNA) and ubiquitylation of its residue K164 have been suggested to play an...
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| Autors principals: | , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2571010/ https://ncbi.nlm.nih.gov/pubmed/18854411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808182105 |
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