Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression

Somatic hypermutation (SHM) and class-switch recombination (CSR) of Ig genes are dependent upon activation-induced cytidine deaminase (AID)-induced mutations. The scaffolding properties of proliferating cell nuclear antigen (PCNA) and ubiquitylation of its residue K164 have been suggested to play an...

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Bibliographische Detailangaben
Hauptverfasser: Roa, Sergio, Avdievich, Elena, Peled, Jonathan U., MacCarthy, Thomas, Werling, Uwe, Kuang, Fei Li, Kan, Rui, Zhao, Chunfang, Bergman, Aviv, Cohen, Paula E., Edelmann, Winfried, Scharff, Matthew D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2571010/
https://ncbi.nlm.nih.gov/pubmed/18854411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808182105
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