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Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo
Hec1 (Highly Expressed in Cancer 1) is one of four proteins of the outer kinetochore Ndc80 complex involved in the dynamic interface between centromeres and spindle microtubules. Its overexpression is seen in a variety of human tumors and correlates with tumor grade and prognosis. We show here that...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2570608/ https://ncbi.nlm.nih.gov/pubmed/18940925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803504105 |
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