Pharmacokinetic and pharmacogenetic determinants of the activity and toxicity of irinotecan in metastatic colorectal cancer patients

This study aims at establishing relationships between genetic and non-genetic factors of variation of the pharmacokinetics of irinotecan and its metabolites; and also at establishing relationships between the pharmacokinetic or metabolic parameters and the efficacy and toxicity of irinotecan. We inc...

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Hlavní autoři: Rouits, E, Charasson, V, Pétain, A, Boisdron-Celle, M, Delord, J-P, Fonck, M, Laurand, A, Poirier, A-L, Morel, A, Chatelut, E, Robert, J, Gamelin, E
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2008
Témata:
Clinical Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570505/
https://ncbi.nlm.nih.gov/pubmed/18797458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604673
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