Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells

BACKGROUND: Resistance to chemotherapy remains one of the principle obstacles to the treatment of colon cancer. In order to identify the molecular mechanism of this resistance, we investigated the role of the steroid and xenobiotic receptor (SXR) in the induction of drug resistance. Indeed, this nuc...

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Detalhes bibliográficos
Main Authors: Basseville, Agnes, Preisser, Laurence, de Carné Trécesson, Sophie, Boisdron-Celle, Michèle, Gamelin, Erick, Coqueret, Olivier, Morel, Alain
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3144021/
https://ncbi.nlm.nih.gov/pubmed/21733184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-80
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