A pharmacokinetic and pharmacodynamic study on metronomic irinotecan in metastatic colorectal cancer patients

The pharmacokinetics (PK) and pharmacodynamics (PD) of metronomic irinotecan have not been studied in cancer patients. The aim of the study is to investigate the PK/PD profile of irinotecan/SN-38 administered by metronomic schedule. Twenty chemotherapy-refractory or chemotherapy-resistant patients w...

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Bibliografische gegevens
Hoofdauteurs: Allegrini, G, Falcone, A, Fioravanti, A, Barletta, M T, Orlandi, P, Loupakis, F, Cerri, E, Masi, G, Di Paolo, A, Kerbel, R S, Danesi, R, Del Tacca, M, Bocci, G
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2008
Onderwerpen:
Clinical Study
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361703/
https://ncbi.nlm.nih.gov/pubmed/18362940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604311
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