Clinical, pharmacokinetic and pharmacodynamic evaluations of metronomic UFT and cyclophosphamide plus celecoxib in patients with advanced refractory gastrointestinal cancers

AIMS: To evaluate UFT and cyclophosphamide (CTX) based metronomic chemotherapy plus celecoxib (CXB) for the treatment of patients with heavily pre-treated advanced gastrointestinal malignancies. METHODS: Thirty-eight patients received 500 mg/mq(2) CTX i.v bolus on day 1 and, from day 2, 50 mg/day CT...

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Hauptverfasser: Allegrini, Giacomo, Di Desidero, Teresa, Barletta, Maria Teresa, Fioravanti, Anna, Orlandi, Paola, Canu, Bastianina, Chericoni, Silvio, Loupakis, Fotios, Di Paolo, Antonello, Masi, Gianluca, Fontana, Andrea, Lucchesi, Sara, Arrighi, Giada, Giusiani, Mario, Ciarlo, Andrea, Brandi, Giovanni, Danesi, Romano, Kerbel, Robert S., Falcone, Alfredo, Bocci, Guido
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Netherlands 2012
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338912/
https://ncbi.nlm.nih.gov/pubmed/22382585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10456-012-9260-6
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