Targeting CD22 Reprograms B-Cells and Reverses Autoimmune Diabetes

OBJECTIVES—To investigate a B-cell–depleting strategy to reverse diabetes in naïve NOD mice. RESEARCH DESIGN AND METHODS—We targeted the CD22 receptor on B-cells of naïve NOD mice to deplete and reprogram B-cells to effectively reverse autoimmune diabetes. RESULTS—Anti-CD22/cal monoclonal antibody (...

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Bibliografiske detaljer
Main Authors: Fiorina, Paolo, Vergani, Andrea, Dada, Shirine, Jurewicz, Mollie, Wong, Masie, Law, Kenneth, Wu, Erxi, Tian, Ze, Abdi, Reza, Guleria, Indira, Rodig, Scott, Dunussi-Joannopoulos, Kyri, Bluestone, Jeffrey, Sayegh, Mohamed H.
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2008
Fag:
Immunology and Transplantation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570398/
https://ncbi.nlm.nih.gov/pubmed/18689692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0420
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