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Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl(−/−) mice
In an N-nitroso-N-ethylurea (ENU) mutagenesis screen using Mpl(−/−) mice, we isolated a semidominant suppressor of thrombocytopenia, termed Plt6. The gene mutated in Plt6 mice encodes the transcriptional coregulator p300, and the mutation, a tyrosine to asparagine substitution at amino acid 630 (Y63...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2569170/ https://ncbi.nlm.nih.gov/pubmed/18684867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-10-119677 |
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