Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene

An N-ethyl-N-nitrosourea mutagenesis screen in mice was performed to isolate regulators of circulating platelet number. We report here recessive thrombocytopenia and kidney disease in plt1 mice, which is the result of a severe but partial loss-of-function mutation in the gene encoding glycoprotein-N...

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Hlavní autoři: Alexander, Warren S., Viney, Elizabeth M., Zhang, Jian-Guo, Metcalf, Donald, Kauppi, Maria, Hyland, Craig D., Carpinelli, Marina R., Stevenson, William, Croker, Ben A., Hilton, Adrienne A., Ellis, Sarah, Selan, Carly, Nandurkar, Harshal H., Goodnow, Christopher C., Kile, Benjamin T., Nicola, Nicos A., Roberts, Andrew W., Hilton, Douglas J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2006
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1637601/
https://ncbi.nlm.nih.gov/pubmed/17062753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607872103
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