A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia

We have generated mice from a N-ethyl-N-nitrosourea mutagenesis screen that carry a mutation in the translation initiation codon of Gata-1, termed Plt13, which is equivalent to mutations found in patients with acute megakaryoblastic leukemia and Down syndrome. The Gata-1 locus is present on the X ch...

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Hlavní autoři: Majewski, Ian J., Metcalf, Donald, Mielke, Lisa A., Krebs, Danielle L., Ellis, Sarah, Carpinelli, Marina R., Mifsud, Sandra, Di Rago, Ladina, Corbin, Jason, Nicola, Nicos A., Hilton, Douglas J., Alexander, Warren S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2006
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1599926/
https://ncbi.nlm.nih.gov/pubmed/16966598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606439103
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