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Characterization of megakaryocyte GATA1-interacting proteins: the corepressor ETO2 and GATA1 interact to regulate terminal megakaryocyte maturation

The transcription factor GATA1 coordinates timely activation and repression of megakaryocyte gene expression. Loss of GATA1 function results in excessive megakaryocyte proliferation and disordered terminal platelet maturation, leading to thrombocytopenia and leukemia in patients. The mechanisms by w...

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Main Authors: Hamlett, Isla, Draper, Julia, Strouboulis, John, Iborra, Francisco, Porcher, Catherine, Vyas, Paresh
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556610/
https://ncbi.nlm.nih.gov/pubmed/18625887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-146605
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