Suppressor screen in Mpl(-/-) mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling

Genetic screens in lower organisms, particularly those that identify modifiers of preexisting genetic defects, have been used successfully to order components of complex signaling pathways. To date, similar suppressor screens have not been used in vertebrates. To define the molecular pathways regula...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Carpinelli, Marina R., Hilton, Douglas J., Metcalf, Donald, Antonchuk, Jennifer L., Hyland, Craig D., Mifsud, Sandra L., Di Rago, Ladina, Hilton, Adrienne A., Willson, Tracy A., Roberts, Andrew W., Ramsay, Robert G., Nicola, Nicos A., Alexander, Warren S.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC404083/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15071178/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0401496101
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