Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl(−/−) mice

In an N-nitroso-N-ethylurea (ENU) mutagenesis screen using Mpl(−/−) mice, we isolated a semidominant suppressor of thrombocytopenia, termed Plt6. The gene mutated in Plt6 mice encodes the transcriptional coregulator p300, and the mutation, a tyrosine to asparagine substitution at amino acid 630 (Y63...

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Detaylı Bibliyografya
Asıl Yazarlar: Kauppi, Maria, Murphy, James M., de Graaf, Carolyn A., Hyland, Craig D., Greig, Kylie T., Metcalf, Donald, Hilton, Adrienne A., Nicola, Nicos A., Kile, Benjamin T., Hilton, Douglas J., Alexander, Warren S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2008
Konular:
Hematopoiesis and Stem Cells
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2569170/
https://ncbi.nlm.nih.gov/pubmed/18684867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-10-119677
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