Increased Dosage of Dyrk1A Alters Alternative Splicing Factor (ASF)-regulated Alternative Splicing of Tau in Down Syndrome

Two groups of tau, 3R- and 4R-tau, are generated by alternative splicing of tau exon 10. Normal adult human brain expresses equal levels of them. Disruption of the physiological balance is a common feature of several tauopathies. Very early in their life, individuals with Down syndrome (DS) develop...

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Detalhes bibliográficos
Main Authors: Shi, Jianhua, Zhang, Tianyi, Zhou, Chunlei, Chohan, Muhammad Omar, Gu, Xiaosong, Wegiel, Jerzy, Zhou, Jianhua, Hwang, Yu-Wen, Iqbal, Khalid, Grundke-Iqbal, Inge, Gong, Cheng-Xin, Liu, Fei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Transcription, Chromatin, and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568927/
https://ncbi.nlm.nih.gov/pubmed/18658135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802645200
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