Cyclic AMP-dependent Protein Kinase Regulates the Alternative Splicing of Tau Exon 10: A MECHANISM INVOLVED IN TAU PATHOLOGY OF ALZHEIMER DISEASE

Hyperphosphorylation and deposition of tau into neurofibrillary tangles is a hallmark of Alzheimer disease (AD). Alternative splicing of tau exon 10 generates tau isoforms containing three or four microtubule binding repeats (3R-tau and 4R-tau), which are equally expressed in adult human brain. Dysr...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Shi, Jianhua, Qian, Wei, Yin, Xiaomin, Iqbal, Khalid, Grundke-Iqbal, Inge, Gu, Xiaosong, Ding, Fei, Gong, Cheng-Xin, Liu, Fei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077661/
https://ncbi.nlm.nih.gov/pubmed/21367856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.204453
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados