Characterization of the Tautomycin Biosynthetic Gene Cluster from Streptomyces spiroverticillatus Unveiling New Insights into Dialkylmaleic Anhydride and Polyketide Biosynthesis

Tautomycin (TTM) is a highly potent and specific protein phosphatase inhibitor isolated from Streptomyces spiroverticillatus. The biological activity of TTM makes it an important lead for drug discovery, whereas its spiroketal-containing polyketide chain and rare dialkylmaleic anhydride moiety draw...

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Bibliografiska uppgifter
Huvudupphovsmän: Li, Wenli, Ju, Jianhua, Rajski, Scott R., Osada, Hiroyuki, Shen, Ben
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2008
Ämnen:
Metabolism and Bioenergetics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568922/
https://ncbi.nlm.nih.gov/pubmed/18708355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804279200
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