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Cathepsin D overexpressed by cancer cells can enhance apoptosis-dependent chemo-sensitivity independently of its catalytic activity
The aspartic protease cathepsin D (cath-D) is a key mediator of induced-apoptosis and its proteolytic activity has been generally involved in this event. During apoptosis, cath-D is translocated to the cytosol. Since cath-D is one of the lysosomal enzymes which requires a more acidic pH to be proteo...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Kluwer Academic/Plenum Publishers
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2568034/ https://ncbi.nlm.nih.gov/pubmed/18497069 |
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