Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line

Survivin is a key cellular protein thought to function in apoptotic regulation, mitotic progression, or possibly both. In this study, we describe the isolation of two conditional knockouts of the survivin gene in chicken DT40 cells. DT40 cells lacking Survivin die in interphase after failing to comp...

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Bibliografiske detaljer
Main Authors: Yue, Zuojun, Carvalho, Ana, Xu, Zhenjie, Yuan, Xuemei, Cardinale, Stefano, Ribeiro, Susana, Lai, Fan, Ogawa, Hiromi, Gudmundsdottir, Elisabet, Gassmann, Reto, Morrison, Ciaran G., Ruchaud, Sandrine, Earnshaw, William C.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2008
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568024/
https://ncbi.nlm.nih.gov/pubmed/18936249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200806118
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