Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line

Survivin is a key cellular protein thought to function in apoptotic regulation, mitotic progression, or possibly both. In this study, we describe the isolation of two conditional knockouts of the survivin gene in chicken DT40 cells. DT40 cells lacking Survivin die in interphase after failing to comp...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yue, Zuojun, Carvalho, Ana, Xu, Zhenjie, Yuan, Xuemei, Cardinale, Stefano, Ribeiro, Susana, Lai, Fan, Ogawa, Hiromi, Gudmundsdottir, Elisabet, Gassmann, Reto, Morrison, Ciaran G., Ruchaud, Sandrine, Earnshaw, William C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2008
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568024/
https://ncbi.nlm.nih.gov/pubmed/18936249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200806118
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