The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpoint

Activation of the anaphase-promoting complex/cyclosome (APC/C) by Cdc20 is critical for the metaphase–anaphase transition. APC/C-Cdc20 is required for polyubiquitination and degradation of securin and cyclin B at anaphase onset. The spindle assembly checkpoint delays APC/C-Cdc20 activation until all...

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Autors principals: Osmundson, Evan C., Ray, Dipankar, Moore, Finola E., Gao, Qingshen, Thomsen, Gerald H., Kiyokawa, Hiroaki
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2008
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568023/
https://ncbi.nlm.nih.gov/pubmed/18852296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200801049
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