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Conformational Changes of α-Chymotrypsin in a Fibrillation-Promoting Condition: A Molecular Dynamics Study
Amyloid nanofibril formation appears to be a generic property of polypeptide chains. α-Chymotrypsin (aCT) was recently driven toward amyloid-like aggregation by the addition of trifluoroethanol (TFE) at intermediate concentrations. In this study we employed a molecular dynamics simulation to investi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2567952/ https://ncbi.nlm.nih.gov/pubmed/18658209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.132407 |
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