The 5-HT(2) antagonist ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels

BACKGROUND AND PURPOSE: Ketanserin, a selective 5-HT receptor antagonist, prolongs the QT interval of ECG in patients. The purpose of the present study was to determine whether ketanserin would block human cardiac ether-à-go-go-related gene (hERG) potassium channels. EXPERIMENTAL APPROACH: Whole-cel...

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書誌詳細
主要な著者: Tang, Q, Li, Z-Q, Li, W, Guo, J, Sun, H-Y, Zhang, X-H, Lau, C-P, Tse, H-F, Zhang, S, Li, G-R
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2008
主題:
Research Papers
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567890/
https://ncbi.nlm.nih.gov/pubmed/18574455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.261
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