Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice

Mucin-type O-glycans (O-glycans) are highly expressed in vascular ECs. However, it is not known whether they are important for vascular development. To investigate the roles of EC O-glycans, we generated mice lacking T-synthase, a glycosyltransferase encoded by the gene C1galt1 that is critical for...

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Bibliographic Details
Main Authors: Fu, Jianxin, Gerhardt, Holger, McDaniel, J. Michael, Xia, Baoyun, Liu, Xiaowei, Ivanciu, Lacramioara, Ny, Annelii, Hermans, Karlien, Silasi-Mansat, Robert, McGee, Samuel, Nye, Emma, Ju, Tongzhong, Ramirez, Maria I., Carmeliet, Peter, Cummings, Richard D., Lupu, Florea, Xia, Lijun
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2008
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567837/
https://ncbi.nlm.nih.gov/pubmed/18924607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36077
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