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Inhibition of poliovirus polymerase by guanidine in vitro.
Extracts from poliovirus-infected HeLa cells synthesized 35s viral RNA, replicative intermediate, and double-stranded RNA in vitro. Guanidine inhibited the synthesis of all three species of RNA; production of 35s RNA was most sensitive to the inhibitor. Pulse-chase experiments with [3H]UTP indicated...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
1982
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC256753/ https://ncbi.nlm.nih.gov/pubmed/6283124 |
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