Inhibition of poliovirus polymerase by guanidine in vitro.
Extracts from poliovirus-infected HeLa cells synthesized 35s viral RNA, replicative intermediate, and double-stranded RNA in vitro. Guanidine inhibited the synthesis of all three species of RNA; production of 35s RNA was most sensitive to the inhibitor. Pulse-chase experiments with [3H]UTP indicated...
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| Udgivet i: | J Virol |
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| Hovedforfatter: | |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology (ASM)
1982
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC256753/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6283124/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.41.1.313-318.1982 |
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