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Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activity
Tumstatin is an angiogenesis inhibitor that binds to αvβ3 integrin and suppresses tumor growth. Previous deletion mutagenesis studies identified a 25-aa fragment of tumstatin (tumstatin peptide) with in vitro antiangiogenic activity. Here, we demonstrate that systemic administration of this tumstati...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2567489/ https://ncbi.nlm.nih.gov/pubmed/18818312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807055105 |
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