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Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activity

Tumstatin is an angiogenesis inhibitor that binds to αvβ3 integrin and suppresses tumor growth. Previous deletion mutagenesis studies identified a 25-aa fragment of tumstatin (tumstatin peptide) with in vitro antiangiogenic activity. Here, we demonstrate that systemic administration of this tumstati...

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Hlavní autoři: Eikesdal, Hans Petter, Sugimoto, Hikaru, Birrane, Gabriel, Maeshima, Yohei, Cooke, Vesselina G., Kieran, Mark, Kalluri, Raghu
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567489/
https://ncbi.nlm.nih.gov/pubmed/18818312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807055105
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