Human α1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by α1β1 integrin

Human noncollagenous domain 1 of the α1 chain of type IV collagen [α1(IV)NC1], or arresten, is derived from the carboxy terminal of type IV collagen. It was shown to inhibit angiogenesis and tumor growth in vivo; however, the mechanisms involved are not known. In the present study we demonstrate tha...

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Main Authors: Sudhakar, Akulapalli, Nyberg, Pia, Keshamouni, Venkateshwar G., Mannam, Arjuna P., Li, Jian, Sugimoto, Hikaru, Cosgrove, Dominic, Kalluri, Raghu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2005
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1199529/
https://ncbi.nlm.nih.gov/pubmed/16151532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24813
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