Regulation of COX-2–mediated signaling by α3 type IV noncollagenous domain in tumor angiogenesis

Human α3 chain, a noncollagenous domain of type IV collagen [α3(IV)NC1], inhibits angiogenesis and tumor growth. These biologic functions are partly attributed to the binding of α3(IV)NC1 to αVβ3 and α3β1 integrins. α3(IV)NC1 binds αVβ3 integrin, leading to translation inhibition by inhibiting focal...

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Detalhes bibliográficos
Main Authors: Boosani, Chandra Shekhar, Mannam, Arjuna P., Cosgrove, Dominic, Silva, Rita, Hodivala-Dilke, Kairbaan M., Keshamouni, Venkateshwar G., Sudhakar, Akulapalli
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1939900/
https://ncbi.nlm.nih.gov/pubmed/17426256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-01-066282
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