Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation

The glycosylphosphatidylinositol (GPI)-anchored proteoglycan Cripto binds Nodal and its type I receptor Alk4 to activate Smad2,3 transcription factors, but a role during Nodal precursor processing has not been described. We show that Cripto also binds the proprotein convertases Furin and PACE4 and l...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Blanchet, Marie-Hélène, Le Good, J Ann, Mesnard, Daniel, Oorschot, Viola, Baflast, Stéphane, Minchiotti, Gabriella, Klumperman, Judith, Constam, Daniel B
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2008
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567404/
https://ncbi.nlm.nih.gov/pubmed/18772886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.174
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg