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The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities

The fate of pluripotent cells in early mouse embryos is controlled by graded Nodal signals that are activated by the endoproteases Furin and Pace4. Soluble forms of Furin and Pace4 cleave proNodal in vitro and after secretion in transfected cells, but direct evidence for paracrine activity in vivo i...

詳細記述

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書誌詳細
主要な著者: Mesnard, Daniel, Donnison, Martyn, Fuerer, Christophe, Pfeffer, Peter L., Constam, Daniel B.
フォーマット: Artigo
言語:Inglês
出版事項: Cold Spring Harbor Laboratory Press 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175722/
https://ncbi.nlm.nih.gov/pubmed/21896659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.16738711
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