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The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities
The fate of pluripotent cells in early mouse embryos is controlled by graded Nodal signals that are activated by the endoproteases Furin and Pace4. Soluble forms of Furin and Pace4 cleave proNodal in vitro and after secretion in transfected cells, but direct evidence for paracrine activity in vivo i...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3175722/ https://ncbi.nlm.nih.gov/pubmed/21896659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.16738711 |
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