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The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities

The fate of pluripotent cells in early mouse embryos is controlled by graded Nodal signals that are activated by the endoproteases Furin and Pace4. Soluble forms of Furin and Pace4 cleave proNodal in vitro and after secretion in transfected cells, but direct evidence for paracrine activity in vivo i...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Mesnard, Daniel, Donnison, Martyn, Fuerer, Christophe, Pfeffer, Peter L., Constam, Daniel B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2011
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175722/
https://ncbi.nlm.nih.gov/pubmed/21896659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.16738711
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